Repose is indicated for the treatment of:
Major Depressive Disorder (MDD)
Obsessive-Compulsive Disorder (OCD)
Panic Disorder (PD)
Post-Traumatic Stress Disorder (PTSD)
Social Anxiety Disorder (SAD)
Premenstrual Dysphoric Disorder (PMDD)
Use only under the supervision of a registered physician.
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Sertraline is a selective serotonin reuptake inhibitor (SSRI) that inhibits CNS neuronal reuptake of serotonin (5-HT), increasing its concentration in the synaptic cleft and prolonging postsynaptic receptor activation. This mechanism improves depressive symptoms and other serotonin-related disorders.
A prolonged elimination half-life allows once-daily dosing.
GI: Nausea, diarrhea, constipation, vomiting, dry mouth, appetite/weight changes
CNS: Drowsiness, dizziness, headache, paresthesia, agitation
Other: Sore throat, pain, excitement
Adults
MDD & OCD: Start 50 mg/day → therapeutic range: 50–200 mg/day
PD, PTSD, SAD: Start 25 mg/day → therapeutic range: 50–200 mg/day
Pediatric (6–12 years) – OCD only
Start 25 mg/day → therapeutic range: 50–200 mg/day
PMDD
Continuous dosing: Start 50 mg/day; may increase by 50 mg per menstrual cycle up to 150 mg/day
Intermittent dosing: Start 50 mg/day, beginning 14 days before menstruation and continuing through onset; may increase up to 100 mg/day in subsequent cycles
Note: Minimum interval between dose adjustments is 1 week.
May displace or be displaced by other highly protein-bound drugs (e.g., warfarin, digitoxin)
Potential interactions with: Cimetidine, CNS depressants (e.g., diazepam), hypoglycemic agents, atenolol, and others
Hypersensitivity to Sertraline or formulation excipients
Moderate to severe hepatic impairment
No evidence of teratogenicity in animals, but human safety not been established
Excreted in breast milk; potential effects on nursing infants unknown
If treatment is essential, breastfeeding should be discontinued
Store below 30°C. Keep away from children.
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